Blood transfusion has been practiced throughout human history from Egyptian antiquity through Ancient Rome and forward to the modern era of hematology. Blood has always been viewed as a sacred entity. Medieval societies regarded blood as an analog to food such that this substance was customarily ingested (rather than being transfused) as part of their religious rituals for rejuvenation, to maintain a youthful life and to mythically “calm the unrestful soul.” In modern medicine, blood transfusion is one the most common therapies used for saving life as a result of severe bleeding and/or anemia.